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A blog by MD ASHFAQ AHMED

Tuesday 3 April 2012

RHIZOPUS SPECIES (microbiology)

13:13    1 comment

Disease caused mucormycosis

Clinical presentation :
       - Rhino-cerebral disease :- unilateral, retro-orbital headache, facial pain, numbness, fever, hyposmia, and nasal stuffiness
       - pulmonary disease :- fever, dyspnea, and cough occasionally hemoptysis
cutaneous disease :- progressive black necrotic lesion
       - GI disease :- abdominal pain, distention, nausea, and vomiting
       - CNS disease :- headache, decreasing consciousness, and focal neurologic symptoms/signs, including cranial nerve deficits
        - Disseminated disease :- involve the kidneys, bones, and heart, with symptoms attributed to these organ systems

Investigations :
      - complete blood cell (CBC)
      - arterial blood gases (ABG)
      - CSF examination
      - CSF and blood culture
      - CT scan and MRI
      - chest X ray
      - biospy

Treatment :
     - prompt institution of liposomal amphoterecin B therapy and surgical resection
     - insulin for diabetic ketoacidosis
     - sodium bicarbonate for acidosis and re-hydration therapy
     - Antifungal treatment consists of lipid formulations of amphotericin B, amphotericin B deoxycholate, or posaconazole. First-line treatment is with an amphotericin derivative.

Prognosis :
      - Mucormycosis carries a mortality rate of 50-85%. The mortality rate associated with rhinocerebral disease is 50-70%. Pulmonary and gastrointestinal (GI) diseases carry an even higher mortality rate, because these forms are typically diagnosed late in the disease course. Disseminated disease carries a mortality rate that approaches 100%

1 comments:

  1. Unknown4 April 2012 at 08:33

    Would you like to get a first-hand look at bread mold?

    Follow these steps:
    1. Slightly moisten a slice of bread; preferably whole wheat bread because the nutrition in white bread is very poor, so fungus does not grow very well on it.

    2. Touch the bread to any surface around you.

    3. Store the bread in a small sealed container or plastic bag, then set it in the warmest place of your house, where it will not dry out.

    4. After a couple days, look at the bread and you will most likely see black specs or other characteristics of the fungus on the surface of the bread.

    **Caution: People with breathing problems or weakened immune systems should not mess with bread mold.

    ReplyDelete